1gtq

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Template:STRUCTURE 1gtq

Contents

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Template:ABSTRACT PUBMED 8137809

Disease

[PTPS_RAT] Note=Deficiency leads to phenylketonuria.

Function

[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

About this Structure

1gtq is a 2 chain structure with sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

  • Nar H, Huber R, Heizmann CW, Thony B, Burgisser D. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis. EMBO J. 1994 Mar 15;13(6):1255-62. PMID:8137809

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