1a1x

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Template:STRUCTURE 1a1x

Contents 1 CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES 2 Disease 3 Function 4 About this Structure 5 Reference

CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES

Template:ABSTRACT PUBMED 9520380

Disease

[MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Function

[MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.^[1]

About this Structure

1a1x is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3413-8. PMID:9520380
• Liang S, Li L, Hsu WL, Pilcher MN, Uversky V, Zhou Y, Dunker AK, Meroueh SO. Exploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculations. Biochemistry. 2009 Jan 20;48(2):399-414. PMID:19113835 doi:10.1021/bi8017043

1. ↑ Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. PMID:10983986