2osg

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Template:STRUCTURE 2osg

Contents

Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2

Template:ABSTRACT PUBMED 17897942

Disease

[ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.[1]

Function

[ZO2_HUMAN] Plays a role in tight junctions and adherens junctions.

About this Structure

2osg is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Wu J, Yang Y, Zhang J, Ji P, Du W, Jiang P, Xie D, Huang H, Wu M, Zhang G, Wu J, Shi Y. Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins. J Biol Chem. 2007 Dec 7;282(49):35988-99. Epub 2007 Sep 25. PMID:17897942 doi:10.1074/jbc.M703826200
  1. ↑ Carlton VE, Harris BZ, Puffenberger EG, Batta AK, Knisely AS, Robinson DL, Strauss KA, Shneider BL, Lim WA, Salen G, Morton DH, Bull LN. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat Genet. 2003 May;34(1):91-6. PMID:12704386 doi:10.1038/ng1147

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