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Template:STRUCTURE 3c6k

Contents 1 Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

Template:ABSTRACT PUBMED 18367445

Disease

[SPSY_HUMAN] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.^[1]

Function

[SPSY_HUMAN] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

About this Structure

3c6k is a 4 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2qfm. Full crystallographic information is available from OCA.

See Also

• Spermidine Synthase

Reference

• Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:http://dx.doi.org/10.1074/jbc.M710323200

1. ↑ Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. PMID:14508504 doi:10.1038/sj.ejhg.5201072