1t2m

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Template:STRUCTURE 1t2m

Contents

Solution Structure Of The Pdz Domain Of AF-6

Template:ABSTRACT PUBMED 15684424

Disease

[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

Function

[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

About this Structure

1t2m is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y. Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. J Biol Chem. 2005 Apr 8;280(14):13841-7. Epub 2005 Jan 31. PMID:15684424 doi:10.1074/jbc.M411065200

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