1ugv

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Template:STRUCTURE 1ugv

Contents 1 Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621) 2 Disease 3 Function 4 About this Structure

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

Disease

[RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

Function

[RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.

About this Structure

1ugv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.