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4hka

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Template:STRUCTURE 4hka

Contents

Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME

Template:ABSTRACT PUBMED 23333332

Function

[T23O_DROME] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring (By similarity). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway.[1]

About this Structure

4hka is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  1. ↑ Searles LL, Ruth RS, Pret AM, Fridell RA, Ali AJ. Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles. Mol Cell Biol. 1990 Apr;10(4):1423-31. PMID:2108317

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