3jto

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Template:STRUCTURE 3jto

Contents

Crystal structure of the c-terminal domain of YpbH

Template:ABSTRACT PUBMED 019801546

Function

[MECA2_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Also involved in Spx degradation by ClpC (By similarity). Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation.[1]

About this Structure

3jto is a 6 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

  1. ↑ Persuh M, Mandic-Mulec I, Dubnau D. A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation. J Bacteriol. 2002 Apr;184(8):2310-3. PMID:11914365

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