2xer

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Template:STRUCTURE 2xer

Contents 1 HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES) 2 Function 3 About this Structure 4 Reference

HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)

Template:ABSTRACT PUBMED 20543818

Function

[PATL1_HUMAN] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).^{[1][2][3][4][5]}

About this Structure

2xer is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J. 2010 Jul 21;29(14):2368-80. Epub 2010 Jun 11. PMID:20543818 doi:10.1038/emboj.2010.124

1. ↑ Scheller N, Resa-Infante P, de la Luna S, Galao RP, Albrecht M, Kaestner L, Lipp P, Lengauer T, Meyerhans A, Diez J. Identification of PatL1, a human homolog to yeast P body component Pat1. Biochim Biophys Acta. 2007 Dec;1773(12):1786-92. Epub 2007 Sep 6. PMID:17936923 doi:10.1016/j.bbamcr.2007.08.009
2. ↑ Scheller N, Mina LB, Galao RP, Chari A, Gimenez-Barcons M, Noueiry A, Fischer U, Meyerhans A, Diez J. Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13517-22. doi:, 10.1073/pnas.0906413106. Epub 2009 Jul 23. PMID:19628699 doi:10.1073/pnas.0906413106
3. ↑ Ozgur S, Chekulaeva M, Stoecklin G. Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies. Mol Cell Biol. 2010 Sep;30(17):4308-23. doi: 10.1128/MCB.00429-10. Epub 2010 Jun , 28. PMID:20584987 doi:10.1128/MCB.00429-10
4. ↑ Totaro A, Renzi F, La Fata G, Mattioli C, Raabe M, Urlaub H, Achsel T. The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. Nucleic Acids Res. 2011 Jan;39(2):635-47. doi: 10.1093/nar/gkq797. Epub 2010 Sep , 17. PMID:20852261 doi:10.1093/nar/gkq797
5. ↑ Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J. 2010 Jul 21;29(14):2368-80. Epub 2010 Jun 11. PMID:20543818 doi:10.1038/emboj.2010.124