3k0c

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Template:STRUCTURE 3k0c

Contents 1 Crystal structure of the phosphorylation-site double mutant S431A/T432E of the KaiC circadian clock protein 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of the phosphorylation-site double mutant S431A/T432E of the KaiC circadian clock protein

Template:ABSTRACT PUBMED 19956664

Function

[KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.^[1][2]

About this Structure

3k0c is a 6 chain structure with sequence from Synechococcus elongatus pcc 7942. Full crystallographic information is available from OCA.

See Also

• Circadian clock protein

Reference

• Pattanayek R, Mori T, Xu Y, Pattanayek S, Johnson CH, Egli M. Structures of KaiC circadian clock mutant proteins: a new phosphorylation site at T426 and mechanisms of kinase, ATPase and phosphatase. PLoS One. 2009 Nov 26;4(11):e7529. PMID:19956664 doi:10.1371/journal.pone.0007529

1. ↑ Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science. 1998 Sep 4;281(5382):1519-23. PMID:9727980
2. ↑ Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T. Global gene repression by KaiC as a master process of prokaryotic circadian system. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):881-5. Epub 2004 Jan 6. PMID:14709675 doi:10.1073/pnas.0307411100