3k10

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Template:STRUCTURE 3k10

Contents

Crystal structure of telomere capping protein Stn1 from Saccharomyces cerevisiae

Template:ABSTRACT PUBMED 19884503

Function

[STN1_YEAST] Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.[1][2]

About this Structure

3k10 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Gelinas AD, Paschini M, Reyes FE, Heroux A, Batey RT, Lundblad V, Wuttke DS. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19298-303. Epub 2009 Nov 2. PMID:19884503
  1. ↑ Grandin N, Reed SI, Charbonneau M. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 1997 Feb 15;11(4):512-27. PMID:9042864
  2. ↑ Grandin N, Damon C, Charbonneau M. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 2001 Mar 1;20(5):1173-83. PMID:11230140 doi:10.1093/emboj/20.5.1173

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