3v62

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Template:STRUCTURE 3v62

Contents 1 Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 2 Function 3 About this Structure 4 See Also 5 Reference

Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164

Template:ABSTRACT PUBMED 22382979

Function

[SMT3_YEAST] Not known; suppressor of MIF2 mutations. [SRS2_YEAST] ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. The polarity of the helicase activity was determined to be 3' to 5'. [PCNA_YEAST] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.^{[1] [2]}

About this Structure

3v62 is a 6 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

See Also

• Proliferating Cell Nuclear Antigen
• SUMO

Reference

1. ↑ Haracska L, Kondratick CM, Unk I, Prakash S, Prakash L. Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell. 2001 Aug;8(2):407-15. PMID:11545742
2. ↑ Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 2002 Sep 12;419(6903):135-41. PMID:12226657 doi:10.1038/nature00991