2ymk

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Template:STRUCTURE 2ymk

Contents

Crystal structure of the hexameric anti-microbial peptide channel dermcidin

Template:ABSTRACT PUBMED 23426625

Function

[DCD_HUMAN] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.[1] Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.[2]

About this Structure

2ymk is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lee Motoyama JP, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-33. Epub 2007 Mar 28. PMID:17448443 doi:10.1016/j.bbrc.2007.03.112
  2. ↑ Lee Motoyama JP, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-33. Epub 2007 Mar 28. PMID:17448443 doi:10.1016/j.bbrc.2007.03.112

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