4hxx

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Template:STRUCTURE 4hxx

Contents 1 Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 2 Function 3 About this Structure 4 Reference

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Template:ABSTRACT PUBMED 23507151

Function

[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.^{[1] [2]}

About this Structure

4hxx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
2. ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291