3k6t

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Template:STRUCTURE 3k6t

Contents 1 Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution 2 Function 3 About this Structure 4 Reference

Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution

Template:ABSTRACT PUBMED 20223220

Function

[GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.

About this Structure

3k6t is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

• Beuck C, Szymczyna BR, Kerkow DE, Carmel AB, Columbus L, Stanfield RL, Williamson JR. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure. 2010 Mar 10;18(3):377-89. PMID:20223220 doi:10.1016/j.str.2009.12.016