3dlw

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Template:STRUCTURE 3dlw

Contents

Antichymotrypsin

Template:ABSTRACT PUBMED 20837024

Function

[AACT_HUMAN] Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.[1]

About this Structure

3dlw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pearce MC, Powers GA, Feil SC, Hansen G, Parker MW, Bottomley SP. Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature. J Mol Biol. 2010 Sep 16. PMID:20837024 doi:10.1016/j.jmb.2010.09.007
  1. ↑ Rubin H, Wang ZM, Nickbarg EB, McLarney S, Naidoo N, Schoenberger OL, Johnson JL, Cooperman BS. Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins. J Biol Chem. 1990 Jan 15;265(2):1199-207. PMID:2404007

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