3kb5

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Template:STRUCTURE 3kb5

Contents 1 PRY-SPRY domain of human TRIM72 2 Function 3 About this Structure 4 Reference

PRY-SPRY domain of human TRIM72

Function

[TRI72_HUMAN] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

About this Structure

3kb5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Park EY, Kwon OB, Jeong BC, Yi JS, Lee CS, Ko YG, Song HK. Crystal structure of PRY-SPRY domain of human TRIM72. Proteins. 2010 Feb 15;78(3):790-5. PMID:19967786 doi:10.1002/prot.22647