2lbu

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Template:STRUCTURE 2lbu

Contents

HADDOCK calculated model of Congo red bound to the HET-s amyloid

Function

[Q03689_PODAN] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.[1] [2] [3]

About this Structure

2lbu is a 5 chain structure with sequence from Podospora anserina. Full experimental information is available from OCA.

Reference

  • Schutz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Bockmann A, Meier BH. The Amyloid-Congo Red Interface at Atomic Resolution. Angew Chem Int Ed Engl. 2011 May 17. doi: 10.1002/anie.201008276. PMID:21591034 doi:10.1002/anie.201008276
  1. ↑ Turcq B, Deleu C, Denayrolles M, Begueret J. Two allelic genes responsible for vegetative incompatibility in the fungus Podospora anserina are not essential for cell viability. Mol Gen Genet. 1991 Aug;228(1-2):265-9. PMID:1886611
  2. ↑ Deleu C, Clave C, Begueret J. A single amino acid difference is sufficient to elicit vegetative incompatibility in the fungus Podospora anserina. Genetics. 1993 Sep;135(1):45-52. PMID:8224826
  3. ↑ Coustou V, Deleu C, Saupe S, Begueret J. The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9773-8. PMID:9275200

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