3l4c

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Template:STRUCTURE 3l4c

Contents 1 Structural basis of membrane-targeting by Dock180 2 Function 3 About this Structure 4 Reference

Structural basis of membrane-targeting by Dock180

Template:ABSTRACT PUBMED 20167601

Function

[DOCK1_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.^[1]

About this Structure

3l4c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Cote JF, Liddington RC. Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem. 2010 Apr 23;285(17):13211-22. Epub 2010 Feb 18. PMID:20167601 doi:10.1074/jbc.M110.102517

1. ↑ Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol. 1996 Apr;16(4):1770-6. PMID:8657152