3kvv

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Template:STRUCTURE 3kvv

Contents

Trapping of an oxocarbenium ion intermediate in UP crystals

Template:ABSTRACT PUBMED 20364833

Function

[UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

About this Structure

3kvv is a 6 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE. Glycal formation in crystals of uridine phosphorylase. Biochemistry. 2010 Apr 27;49(16):3499-509. PMID:20364833 doi:10.1021/bi902073b

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