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3ld1
From Proteopedia
Crystal Structure of IBV Nsp2a
Function
[R1A_IBVM] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
About this Structure
3ld1 is a 1 chain structure with sequence from Viruses. Full crystallographic information is available from OCA.
Categories: Viruses | Bartlam, M. | Chen, C. | Cong, L. | Fu, J. | Rao, Z. | Tang, H. | Wei, L. | Xu, Y. | Yang, A. | Globular like | Host cytoplasm | Host membrane | Hydrolase | Membrane | Metal-binding | Protease | Rna-binding | Thiol protease | Transmembrane | Zinc-finger
