3ksl

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Template:STRUCTURE 3ksl

Contents

Structure of FPT bound to DATFP-DH-GPP

Template:ABSTRACT PUBMED 19954434

Function

[FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

About this Structure

3ksl is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Hovlid ML, Edelstein RL, Henry O, Ochocki J, DeGraw A, Lenevich S, Talbot T, Young VG, Hruza AW, Lopez-Gallego F, Labello NP, Strickland CL, Schmidt-Dannert C, Distefano MD. Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chem Biol Drug Des. 2010 Jan;75(1):51-67. PMID:19954434 doi:10.1111/j.1747-0285.2009.00914.x

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