This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3lgg
From Proteopedia
Contents |
Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2) complexed with transition state analogue, coformycin
Template:ABSTRACT PUBMED 20147294
Disease
[CECR1_HUMAN] Cat-eye syndrome.
Function
[CECR1_HUMAN] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.[1] [2]
About this Structure
3lgg is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527
- ↑ Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010 Aug;88(2):279-90. doi: 10.1189/jlb.1109764. Epub 2010 May 7. PMID:20453107 doi:10.1189/jlb.1109764
- ↑ Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527
