3l32
From Proteopedia
Contents |
Structure of the dimerisation domain of the rabies virus phosphoprotein
Template:ABSTRACT PUBMED 20089657
Function
[PHOSP_RABVR] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).
About this Structure
3l32 is a 2 chain structure with sequence from Rabies virus. Full crystallographic information is available from OCA.
Reference
- Ivanov I, Crepin T, Jamin M, Ruigrok RW. Structure of the dimerization domain of the rabies virus phosphoprotein. J Virol. 2010 Apr;84(7):3707-10. Epub 2010 Jan 20. PMID:20089657 doi:10.1128/JVI.02557-09
