3l0h

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3l0h

Contents 1 Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione

Template:ABSTRACT PUBMED 20833278

Function

[GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.^[1]

About this Structure

3l0h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Glutathione S-transferase

Reference

• Balchin D, Fanucchi S, Achilonu I, Adamson RJ, Burke J, Fernandes M, Gildenhuys S, Dirr HW. Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1. Biochim Biophys Acta. 2010 Sep 15. PMID:20833278 doi:10.1016/j.bbapap.2010.09.003

1. ↑ Achilonu I, Gildenhuys S, Fisher L, Burke J, Fanucchi S, Sewell BT, Fernandes M, Dirr HW. The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt, 7):776-80. Epub 2010 Jun 23. PMID:20606271 doi:10.1107/S1744309110019135