3lgd

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Template:STRUCTURE 3lgd

Contents 1 Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2) 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)

Template:ABSTRACT PUBMED 20147294

Disease

[CECR1_HUMAN] Cat-eye syndrome.

Function

[CECR1_HUMAN] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.^{[1] [2]}

About this Structure

3lgd is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527

1. ↑ Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010 Aug;88(2):279-90. doi: 10.1189/jlb.1109764. Epub 2010 May 7. PMID:20453107 doi:10.1189/jlb.1109764
2. ↑ Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527