This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4i06
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhibitor 14
Template:ABSTRACT PUBMED 23472952
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4i06 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Arginase | Homo sapiens | Andreoli, M. | Beckett ,P. | Conway, B. | Cousido-Siah, A. | Golebiowski, A. | Ji, M. | Mahboubi, K. | Mitschler, A. | Podjarny, A. | Ruiz, F X. | Schroeter, H. | Sheeler, R. | Whitehouse, D L. | Zandt, M C.Van. | Zhang, M. | Alpha/beta fold | Arginine metabolism | Hydrolase | Manganese | Metalloenzyme | Mitochondrion
