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2c8a

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Template:STRUCTURE 2c8a

Contents

STRUCTURE OF THE WILD-TYPE C3BOT1 EXOENZYME (NICOTINAMIDE-BOUND STATE, CRYSTAL FORM I)

Template:ABSTRACT PUBMED 18369192

Function

[ARC3_CBDP] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.

About this Structure

2c8a is a 4 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

  • Menetrey J, Flatau G, Boquet P, Menez A, Stura EA. Structural basis for the NAD-hydrolysis mechanism and the ARTT-loop plasticity of C3 exoenzymes. Protein Sci. 2008 May;17(5):878-86. Epub 2008 Mar 27. PMID:18369192 doi:10.1110/ps.073398508
  • Menetrey J, Flatau G, Stura EA, Charbonnier JB, Gas F, Teulon JM, Le Du MH, Boquet P, Menez A. NAD binding induces conformational changes in Rho ADP-ribosylating clostridium botulinum C3 exoenzyme. J Biol Chem. 2002 Aug 23;277(34):30950-7. Epub 2002 May 23. PMID:12029083 doi:10.1074/jbc.M201844200

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OCA

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