3m5b
From Proteopedia
Contents |
Crystal structure of the BTB domain from FAZF/ZBTB32
Template:ABSTRACT PUBMED 20493880
Function
[ZBT32_HUMAN] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).[1]
About this Structure
3m5b is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Prive GG. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. J Mol Biol. 2010 Jul 30;400(5):983-97. Epub 2010 May 21. PMID:20493880 doi:10.1016/j.jmb.2010.05.028
- ↑ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 1999 Dec 1;94(11):3737-47. PMID:10572087
Categories: Homo sapiens | Pomroy, N C. | Prive, G G. | Stogios, P J. | Alpha/beta protein | Btb domain | Btb/poz domain | Dna binding protein | Dna-binding | Fancc-interacting protein | Fanconi anemia zinc finger protein | Faxf | Fazf | Metal-binding | Nucleus | Poz domain | Protein-protein interaction domain | Repressor | Rog | Testis zinc finger protein | Transcription | Transcription regulation | Transcription regulator | Tzfp | Zbtb32 | Zinc finger and btb domain-containing protein 32 | Zinc-finger | Zinc-finger protein | Znf538
