3mof

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Template:STRUCTURE 3mof

Contents 1 The structure of rat cytosolic PEPCK mutant A467G in complex with oxalate and GTP 2 Function 3 About this Structure 4 See Also 5 Reference

The structure of rat cytosolic PEPCK mutant A467G in complex with oxalate and GTP

Template:ABSTRACT PUBMED 20476774

Function

[PCKGC_RAT] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

About this Structure

3mof is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

See Also

• Phosphoenolpyruvate carboxykinase

Reference

• Johnson TA, Holyoak T. Increasing the conformational entropy of the Omega-loop lid domain in PEPCK impairs catalysis and decreases catalytic fidelity. Biochemistry. 2010 May 17. PMID:20476774 doi:10.1021/bi100399e