3mjr

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3mjr

Contents 1 Human dCK complex with Acyclic Nucleoside 2 Function 3 About this Structure 4 Reference

Human dCK complex with Acyclic Nucleoside

Template:ABSTRACT PUBMED 20684612

Function

[DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.^{[1] [2]}

About this Structure

3mjr is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Hazra S, Konrad M, Lavie A. The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues. J Med Chem. 2010 Aug 12;53(15):5792-800. PMID:20684612 doi:10.1021/jm1005379

1. ↑ Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. Epub 2008 Mar 3. PMID:18377927 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.061
2. ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e