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3n7o

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Template:STRUCTURE 3n7o

Contents

X-ray structure of human chymase in complex with small molecule inhibitor.

Template:ABSTRACT PUBMED 20599788

Function

[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

About this Structure

3n7o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Potency variation of small-molecule chymase inhibitors across species. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. Epub 2010 Jun 23. PMID:20599788 doi:10.1016/j.bcp.2010.06.014

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OCA

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