2m0y

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Template:STRUCTURE 2m0y

Solution structure of the SH3 domain of DOCK180

Template:ABSTRACT PUBMED 23239367

Function

[DOCK1_MOUSE] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (By similarity).

About this Structure

2m0y is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

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