4fxd

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Template:STRUCTURE 4fxd

Contents 1 Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA 2 Function 3 About this Structure 4 Reference

Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA

Function

[DPOA_YEAST] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) consitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13.^[1]

About this Structure

4fxd is a 6 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

1. ↑ Qi H, Zakian VA. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev. 2000 Jul 15;14(14):1777-88. PMID:10898792