2f44
From Proteopedia
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Crystal Structure of the Zinc-bound Shank SAM domain
Overview
The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
About this Structure
2F44 is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Full crystallographic information is available from OCA.
Reference
An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662
Page seeded by OCA on Thu Feb 21 17:17:30 2008
Categories: Rattus norvegicus | Single protein | Baron, M K. | Bowie, J U. | Faham, S. | CL | ZN | Post-synaptic density | Sam domain | Scaffolding protein | Shank | Zinc
