3nis

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Template:STRUCTURE 3nis

Contents 1 The structure of UBR box (native2) 2 Function 3 About this Structure 4 See Also 5 Reference

The structure of UBR box (native2)

Template:ABSTRACT PUBMED 20835240

Function

[UBR1_YEAST] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

About this Structure

3nis is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

• Ubiquitin protein ligase

Reference

• Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240 doi:10.1038/nsmb.1907