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3nvx

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Template:STRUCTURE 3nvx

Contents

Molecular mechanism of guidance cue recognition

Template:ABSTRACT PUBMED 20727575

Function

[VA39_VACCC] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of host plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection (By similarity).

About this Structure

3nvx is a 2 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

  • Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575 doi:10.1016/j.cell.2010.07.040

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OCA

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