3o3r

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Template:STRUCTURE 3o3r

Contents

Crystal Structure of AKR1B14 in complex with NADP

Template:ABSTRACT PUBMED 21168333

Function

[Q5RJP0_RAT] Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes.[1]

About this Structure

3o3r is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O. Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis. Bioorg Med Chem Lett. 2011 Jan 15;21(2):801-4. Epub 2010 Nov 24. PMID:21168333 doi:10.1016/j.bmcl.2010.11.086
  1. ↑ Endo S, Matsunaga T, Fujita A, Tajima K, El-Kabbani O, Hara A. Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal. Biol Pharm Bull. 2010;33(11):1886-90. PMID:21048316

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