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3o47
From Proteopedia
Crystal structure of ARFGAP1-ARF1 fusion protein
Function
[ARFG1_HUMAN] GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
About this Structure
3o47 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Arrowsmith, C H. | Bochkarev, A. | Bountra, C. | Crombet, L. | Edwards, A M. | Guan, X. | Nedyalkova, L. | Park, H. | SGC, Structural Genomics Consortium. | Tempel, W. | Tong, Y. | Wang, H. | Weigelt, J. | Chimera protein | Fusion protein | Gtpase activation | Hydrolase | Hydrolase activator | Sgc | Structural genomics consortium
