3nt7

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Template:STRUCTURE 3nt7

Contents

Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase R187V Mutant

Template:ABSTRACT PUBMED 20861259

Function

[UNG_VACCA] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.

About this Structure

3nt7 is a 2 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

  • Druck Shudofsky AM, Silverman JE, Chattopadhyay D, Ricciardi RP. Vaccinia virus D4 mutants defective in processive DNA synthesis retain binding to A20 and DNA. J Virol. 2010 Dec;84(23):12325-35. Epub 2010 Sep 22. PMID:20861259 doi:10.1128/JVI.01435-10

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