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2yg2

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Template:STRUCTURE 2yg2

Contents

STRUCTURE OF APOLIOPROTEIN M IN COMPLEX WITH SPHINGOSINE 1-PHOSPHATE

Template:ABSTRACT PUBMED 21606363

Function

[APOM_HUMAN] Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.[1] [2]

About this Structure

2yg2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnstrom J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlback B. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. Epub 2011 May 23. PMID:21606363 doi:10.1073/pnas.1103187108
  1. ↑ Ahnstrom J, Faber K, Axler O, Dahlback B. Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. J Lipid Res. 2007 Aug;48(8):1754-62. Epub 2007 May 24. PMID:17525477 doi:10.1194/jlr.M700103-JLR200
  2. ↑ Sevvana M, Ahnstrom J, Egerer-Sieber C, Lange HA, Dahlback B, Muller YA. Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M. J Mol Biol. 2009 Nov 6;393(4):920-36. Epub 2009 Sep 4. PMID:19733574 doi:10.1016/j.jmb.2009.08.071

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