2f87
From Proteopedia
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Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus
Overview
The NMR structure of a 12-mer RNA derived from the helix 6 of SRP RNA from Pyrococcus furiosus, whose loop-closing base pair is U.G, was determined, and the structural and thermodynamic properties of the RNA were compared with those of a mutant RNA with the C:G closing base pair. Although the structures of the two RNAs are similar to each other and adopt the GNRR motif the conformational stabilities are significantly different to each other It was suggested that weaker stacking interaction of the GAAG loop with the U:G closing base pair in 12-mer RNA causes the lower conformational stability.
About this Structure
2F87 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus., Okada K, Takahashi M, Sakamoto T, Kawai G, Nakamura K, Kanai A, Nucleosides Nucleotides Nucleic Acids. 2006;25(4-6):383-95. PMID:16838833
Page seeded by OCA on Thu Feb 21 17:18:42 2008
Categories: Protein complex | Kanai, A. | Kawai, G | Nakamura, K. | Okada, K. | Sakamoto, T. | Takahashi, M. | Gnrr | Rna | Srp
