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3nds

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Template:STRUCTURE 3nds

Contents

Crystal structure of engineered Naja Nigricollis toxin alpha

Template:ABSTRACT PUBMED 20804768

Function

[NXS1_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.[1]

About this Structure

3nds is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gross G, Gallopin M, Vandame M, Couprie J, Stura E, Zinn-Justin S, Drevet P. Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines. J Mol Biol. 2010 Oct 22;403(2):299-312. Epub 2010 Sep 8. PMID:20804768 doi:10.1016/j.jmb.2010.07.048
  1. ↑ Servent D, Winckler-Dietrich V, Hu HY, Kessler P, Drevet P, Bertrand D, Menez A. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. PMID:9305882

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