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3o4z

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Template:STRUCTURE 3o4z

Contents

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

Template:ABSTRACT PUBMED 20801936

Function

[TEL2_YEAST] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.

About this Structure

3o4z is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Takai H, Xie Y, de Lange T, Pavletich NP. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 2010 Aug 27. PMID:20801936 doi:10.1101/gad.1956410

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OCA

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