3np1

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Template:STRUCTURE 3np1

Contents

CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE

Template:ABSTRACT PUBMED 9546222

Function

[NP1_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing.

About this Structure

3np1 is a 2 chain structure with sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.

Reference

  • Weichsel A, Andersen JF, Champagne DE, Walker FA, Montfort WR. Crystal structures of a nitric oxide transport protein from a blood-sucking insect. Nat Struct Biol. 1998 Apr;5(4):304-9. PMID:9546222
  • Yang F, Zhang H, Knipp M. A one-residue switch reverses the orientation of a heme b cofactor. Investigations of the ferriheme NO transporters nitrophorin 2 and 7 from the blood-feeding insect Rhodnius prolixus. Biochemistry. 2009 Jan 20;48(2):235-41. PMID:19140692 doi:10.1021/bi8020229

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