3o76

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Template:STRUCTURE 3o76

Contents

1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione

Template:ABSTRACT PUBMED 21134126

Function

[GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).

About this Structure

3o76 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • McManus G, Costa M, Canals A, Coll M, Mantle TJ. Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione. FEBS J. 2011 Jan;278(2):273-81. doi: 10.1111/j.1742-4658.2010.07944.x., Epub 2010 Dec 6. PMID:21134126 doi:10.1111/j.1742-4658.2010.07944.x

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