Sandbox Reserved 694

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This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.

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THE ANTHRAX PROTECTIVE ANTIGEN

spinqualitylabelsall models Anthrax protective antigen complex (blue) with stabilizing Ca2+ (green) (PDB ID: 1ACC) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

by Matt Wier

Tetrameric Structure

The is a tetrameric protein that functions to bind to host receptors on the plasma membrane to translocate the anthrax toxin factors into the host cell. The monomer form contains that each serve unique functions. The contains a Furin cleavage site, the binding site for the toxin factors, and two Calcium ions (green) for stabilizaion. The contains a flexible loop to aid in plasma membrane insertion. The interacts with other PA's in the heptamer form. The is the most important domain because it can undergo a conformational change to allow heptamerization to occur. Monomer PA's must oligomerize to form a before it can bind to host receptors and translocate the toxin into the cell.