Sandbox Reserved 696

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This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.

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Contents 1 Background 2 NMDAR Structure 3 NMDAR Binding Sites 4 NMDAR Ion Channel 5 Excitotoxicity and Disease 6 Memantine Uses

Background

neurotransmitter ion channels whose flux controls what

NMDAR Structure

general structure subunits interactions between subunits

NMDAR Binding Sites

places for ligand, agonist, antagonist interactions by which they bind which subunit they bind to

NMDAR Ion Channel

agonist bind, then conformational change, then ion flux in

Excitotoxicity and Disease

define excitotoxicity excitotoxicity role in disease

Memantine Uses

recreational drugs Parkinson, Alzheimers, Etc.