3zn3
From Proteopedia
Contents |
N-terminal domain of S. pombe Cdc23 APC subunit
Template:ABSTRACT PUBMED 23583778
Function
[APC8_SCHPO] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.[1]
About this Structure
3zn3 is a 1 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
