2fhy

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Image:2fhy.gif

2fhy, resolution 2.95Å

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Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

Contents

Overview

We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.

Disease

Known disease associated with this structure: Fructose-1,6-bidphosphatase deficiency OMIM:[611570]

About this Structure

2FHY is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Fructose-bisphosphatase, with EC number 3.1.3.11 Full crystallographic information is available from OCA.

Reference

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:16442285

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